Industry’s first FDA clearance for the analysis of neuromelanin MRI
Neuromelanin is a molecule associated with dopamine and norepinephrine neurons in the brain. Over the last two decades, researchers have elucidated its possible role as a biomarker for neurological and psychiatric disorders [1-6].
Seamless integration into existing workflows brings the potential of neuromelanin MRI to patients and neuroradiologists
NM-101’s cloud-based service integrates into existing hospital picture archiving systems (PACS) to process post-acquisition brain MRI sequences. MRI images can be sent to NM-101 directly through the PACS and a full analysis report returned in under an hour.
Novel technology enables the fully automated analysis of neuromelanin associated signal in both the substantia nigra and locus coeruleus
Terran’s NM-101 post-acquisition software uses both validated voxel-based and segmented based methods to process and analyze post-acquisition MRI images. NM-101 automatically calculates and visualizes the levels and volumes of neuromelanin associated contrast to noise ratio (CNR) signal in the substantia nigra and locus coeruleus regions of the brain and creates a neuromelanin report. NM-101 delivers clinically relevant information such as tissue volumes, qualitative parametric maps, and degree of neuromelanin associated CNR signal in the midbrain. Changes in brain levels and volumes of neuromelanin associated CNR signal can be tracked over time, for use as an adjunct to diagnosis.
Cross-scanner variability in neuromelanin MRI solved with harmonization
No radiation exposure
No IV infusion and no contrast agent required
Fast scan time: can be added onto a standard non-contrast brain MRI
Uses a standard brain MRI spin sequence: Turbo Spin Echo
Adjunctive tool to aid neuroradiologists in the differential diagnosis and monitoring of dopamine-related diseases